2019
Costas L, Palomero L, Benavente Y, Guardiola M, Frias-Gomez J, Pavón MÁ, Climent M, Martinez JM, Barahona M, Salinas M, Pineda M, Bianchi I, Reventós J, Capellà G, Diaz M, Vidal A, Piulats JM, Ponce J, Brunet J, Bosch FX, Matias-Guiu X, Alemany L, de Sanjosé S, Aytes A; Screenwide Team. Defining a mutational signature for endometrial cancer screening and early detection. Cancer Epidemiol. 2019 Aug;61:129-132. doi: 10.1016/j.canep.2019.06.003. Epub 2019 Jun 22.
Costas L, Frias-Gomez J, Guardiola M, Benavente Y, Pineda M, Pavón MÁ, Martínez JM, Climent M, Barahona M, Canet J, Paytubi S, Salinas M, Palomero L, Bianchi I, Reventós J, Capellà G, Diaz M, Vidal A, Piulats JM, Aytés Á, Ponce J, Brunet J, Bosch FX, Matias-Guiu X, Alemany L, de Sanjosé S; Screenwide Team. New perspectives on screening and early detection of endometrial cancer. Int J Cancer. 2019 Jun 14. doi: 10.1002/ijc.32514.
Nombela P, Lozano R, Aytes A, Mateo J, Olmos D, Castro E. BRCA2 and Other DDR Genes in Prostate Cancer. Cancers (Basel). 2019 Mar 12;11(3). pii: E352. doi: 10.3390/cancers11030352
Costas L, Frias-Gomez J, Guardiola M, Benavente Y, Pineda M, Pavón MÁ, Martínez JM, Climent M, Barahona M, Canet J, Paytubi S, Salinas M, Palomero L, Bianchi I, Reventós J, Capellà G, Diaz M, Vidal A, Piulats JM, Aytés Á, Ponce J, Brunet J, Bosch FX, Matias-Guiu X, Alemany L, de Sanjosé S; Screenwide Team. New perspectives on screening and early detection of endometrial cancer. Int J Cancer. 2019 Jun 14. doi: 10.1002/ijc.32514.
Nombela P, Lozano R, Aytes A, Mateo J, Olmos D, Castro E. BRCA2 and Other DDR Genes in Prostate Cancer. Cancers (Basel). 2019 Mar 12;11(3). pii: E352. doi: 10.3390/cancers11030352
2018
Ruggero K, Farran-Matas S, Martinez-Tebar A, Aytes A. Epigenetic Regulation in Prostate Cancer Progression. Curr Mol Biol Rep. 2018;4(2):101-115. doi: 10.1007/s40610-018-0095-9
Aytes A*, Giacobbe A, Mitrofanova A, Ruggero K, Cyrta J, Arriaga J, Palomero L, Farran-Matas S, Rubin MA, Shen MM, Califano A, Abate-Shen C. NSD2 is a conserved driver of metastatic prostate cancer progression. Nat Commun. 2018 Dec 5;9(1):5201. doi: 10.1038/s41467-018-07511-4. *(Co-corresponding)
Piulats JM, Vidal A, García-Rodríguez FJ, Muñoz C, Nadal M, Moutinho C, Martínez-Iniesta M, Mora J, Figueras A, Guinó E, Padullés L, Aytés À, Molleví DG, Puertas S, Martínez-Fernández C, Castillo W, Juliachs M, Moreno V, Muñoz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germà JR, Capella G, Farré L, Morales A, Viñals F, García-Del-Muro X, Cerón J, Villanueva A. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018 Apr 4. doi: 10.1158/1078-0432.CCR-17-1898
Aytes A*, Giacobbe A, Mitrofanova A, Ruggero K, Cyrta J, Arriaga J, Palomero L, Farran-Matas S, Rubin MA, Shen MM, Califano A, Abate-Shen C. NSD2 is a conserved driver of metastatic prostate cancer progression. Nat Commun. 2018 Dec 5;9(1):5201. doi: 10.1038/s41467-018-07511-4. *(Co-corresponding)
Piulats JM, Vidal A, García-Rodríguez FJ, Muñoz C, Nadal M, Moutinho C, Martínez-Iniesta M, Mora J, Figueras A, Guinó E, Padullés L, Aytés À, Molleví DG, Puertas S, Martínez-Fernández C, Castillo W, Juliachs M, Moreno V, Muñoz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germà JR, Capella G, Farré L, Morales A, Viñals F, García-Del-Muro X, Cerón J, Villanueva A. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018 Apr 4. doi: 10.1158/1078-0432.CCR-17-1898
2015
Mitrofanova A*, Aytes A*, Zou M, Shen MM, Abate-Shen C, Califano A. Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models. Cell Rep. 2015 Sep 29;12(12):2060-71
Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13;28(1):97-113.
Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13;28(1):97-113.
Aytes, A., Mitrofanova, A, Lefebvre, C, Alvarez, MJ, Castillo-Martin, M., Zheng, T., Eastham, JA, Gopalan, A., Pienta, K.J., Shen, M.M., Califano, A., & Abate-Shen, C. (2014) Cross-species analysis of genome-wide regulatory networks identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell 25(5); 638-651
Highlights in: Lokody, I. (2014), Nature Reviews Cancer, 7, 450
Highlights in: Lokody, I. (2014), Nature Reviews Cancer, 7, 450
Aytes, A., Mitrofanova, A., Kinkade, C.W., Lefebvre, C., Lei, M., Phelan, V., Lekaye, H.C., Koutcher, J.A., Cardiff, R.D., Califano, A., Shen, M.M., & Abate-Shen, C. (2013) ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A 110(37):E3506-3515.
Highlights in: Baker, S.J. and Reddy, E.P. (2013), Proc. of the Nat. Acad. of Sciences USA, 37, 14819
Grabowska, M.M. et al., (2014), Cancer and Metastasis Reviews, 33, 377
Irshad, S., Bansal, M., Castillo-Martin, M., Zheng, T., Aytes, A., Wenske, S., Le Magnen, C., Guarnieri, P., Sumazin, P., Benson, M.C., Shen, M.M., Califano, A., & Abate-Shen, C. (2013) A molecular signature predictive of indolent prostate cancer. Science Translational Medicine 5(202):202ra122.
Highlights in: Baker, S.J. and Reddy, E.P. (2013), Proc. of the Nat. Acad. of Sciences USA, 37, 14819
Grabowska, M.M. et al., (2014), Cancer and Metastasis Reviews, 33, 377
Irshad, S., Bansal, M., Castillo-Martin, M., Zheng, T., Aytes, A., Wenske, S., Le Magnen, C., Guarnieri, P., Sumazin, P., Benson, M.C., Shen, M.M., Califano, A., & Abate-Shen, C. (2013) A molecular signature predictive of indolent prostate cancer. Science Translational Medicine 5(202):202ra122.
Wang, J., Kobayashi, T., Floc'h, N., Kinkade, C.W., Aytes, A., Dankort, D., Lefebvre, C., Mitrofanova, A., Cardiff, R.D., McMahon, M., Califano, A., Shen, M.M., & Abate-Shen, C. (2012) B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res 72(18):4765-4776.
Floc'h, N., Kinkade, C.W., Kobayashi, T., Aytes, A., Lefebvre, C., Mitrofanova, A., Cardiff, R.D., Califano, A., Shen, M.M., & Abate-Shen, C. (2012) Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res 72(17):4483-4493.
Aytes, A., Mollevi, D.G., Martinez-Iniesta, M., Nadal, M., Vidal, A., Morales, A., Salazar, R., Capella, G., & Villanueva, A. (2012) Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Molecular carcinogenesis 51(9):746-753.
Floc'h, N., Kinkade, C.W., Kobayashi, T., Aytes, A., Lefebvre, C., Mitrofanova, A., Cardiff, R.D., Califano, A., Shen, M.M., & Abate-Shen, C. (2012) Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res 72(17):4483-4493.
Aytes, A., Mollevi, D.G., Martinez-Iniesta, M., Nadal, M., Vidal, A., Morales, A., Salazar, R., Capella, G., & Villanueva, A. (2012) Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Molecular carcinogenesis 51(9):746-753.
Melo, S., Villanueva, A., Moutinho, C., Davalos, V., Spizzo, R., Ivan, C., Rossi, S., Setien, F., Casanovas, O., Simo-Riudalbas, L., Carmona, J., Carrere, J., Vidal, A., Aytes, A., Puertas, S., Ropero, S., Kalluri, R., Croce, C.M., Calin, G.A., & Esteller, M. (2011) Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A 108(11):4394-4399.
Maxwell, C.A., Benitez, J., Gomez-Baldo, L., Osorio, A., Bonifaci, N., Fernandez-Ramires, R., Costes, S.V., Guino, E., Chen, H., Evans, G.J., Mohan, P., Catala, I., Petit, A., Aguilar, H., Villanueva, A., Aytes, A., et al. (2011) Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 9(11):e1001199.
Maxwell, C.A., Benitez, J., Gomez-Baldo, L., Osorio, A., Bonifaci, N., Fernandez-Ramires, R., Costes, S.V., Guino, E., Chen, H., Evans, G.J., Mohan, P., Catala, I., Petit, A., Aguilar, H., Villanueva, A., Aytes, A., et al. (2011) Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 9(11):e1001199.
Mollevi, D.G., Aytes, A., Berdiel, M., Padulles, L., Martinez-Iniesta, M., Sanjuan, X., Salazar, R., & Villanueva, A. (2009) PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts. Molecular Cancer 8:46.
Mollevi, D.G., Aytes, A., Padulles, L., Martinez-Iniesta, M., Baixeras, N., Salazar, R., Ramos, E., Figueras, J., Capella, G., & Villanueva, A. (2008) PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness. British journal of cancer 99(10):1718-1725.
Fernandez-Majada, V., Aguilera, C., Villanueva, A., Vilardell, F., Robert-Moreno, A., Aytes, A., Real, F.X., Capella, G., Mayo, M.W., Espinosa, L., & Bigas, A. (2007) Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc Natl Acad Sci U S A 104(1):276-281.
